Specific effective therapy in the enteric fevers only became
available in 1948 with the introduction of chloramphenical. Before the
introduction of chloramphenical good home care and the patient own defense
mechanism was the only hope recovery.
Chloramphenical therapy as already noted has usually been
accompanied by a higher relapse rate although .Some author claim that for one
to prevent this increase in relapses by varying the dosage and duration of
chloramphenical therapy and using TAB vaccine therapeutically. Although
chloramphenical remains the drug of first choice, its use in contraindicated if
the infecting strain is resistant to the drug.
is rare. However incase of resistant Contrimoxazole or semi-synthetic
penicillin such as ampicillin, amoxycillin or mecillinam may be prescribed as